Once her father is dead she can be cured but you cannot convince her. Of the dialog options choosing "how are you feeling? If the player asks her directly if she wants a cure Serana will become defensive making it impossible to ever cure her. It is unknown as to when she will become unresponsive but it is confirmed that she will only consider a cure after her father is dead Well dead for the last time. It's like Kunigonde said, it's in the dialog options.
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How do you cure Serana of vampirism? : V - Skyrim
Return to V - Skyrim. How do you cure Serana of vampirism? Make sure to save a lot through your playthrough so you can backtrack when necessary. Only downsides imo? No matter though, mods will take care of that, and she will finally be free of the dark arts! Still can't get her to say "yup, good idea there, drageebornee.
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